d4zux.netlify.com

1. Top 10 Worst Sports Injuries
2. The Acupuncture Handbook Of Sports Injuries & Pain
3. Sports Injuries Elbow
4. The Acupuncture Handbook Of Sports Injuries Pain Pdf Writer Free
5. Youth Sports Injuries
6. The Acupuncture Handbook Of Sports Injuries Pain Pdf Writer
7. Sports Injuries Statistics

In traditional Chinese medicine like acupuncture, the flow of energy, or qi, through the 12 meridians (6 yin and 6 yang meridians) is thought to be highest for a two-hour period every day at each organ. Acupuncturists use this information diagnostically, as well as to determine the optimal time for treating specific imbalances.

The Acupuncture Handbook of Sports Injuries and Pain is a clinical manual that integrates traditional Chinese acupuncture with western orthopedic and sports medicine. It outlines the diagnosis, assessment, and treatment protocol for 25 common sports injuries. The Acupuncture Handbook offers both insight and discipline for treating injuries and pain. [PDF] The Acupuncture Handbook of Sports Injuries Pain: A Four Step Approach to Treatment Full. 2 tahun yang lalu 19 views. He is a contributing writer toThe Acupuncture Handbook. TheAcupuncture Handbook uses a simple Four Step approach, making point selection and needle technique simple, logical, and systematic. Item 1 The Acupuncture Handbook of Sports Injuries & Pain by Whitfield Reaves - The Acupuncture Handbook of Sports Injuries & Pain by Whitfield Reaves. Fast Pain Relief With Tung’s Acupuncture and Chinese Herbs for 8 credits sponsored by Lotus. Treating Sports Injuries with Acupuncture, Tuina and TCM for 2 credits; (2) Lower Back Pain: Assessment, Red. Pain Management Clinical Handbook for Acupuncturists for 2 credits. Rescue the Root: Cupping the Navel for 2 hours sponsored. The Acupuncture Handbook of Sports Injuries & Pain: A Four Step Approach to Treatment. Whitfield Reaves. Insights of a Senior Acupuncturist. The Acupuncture Handbook of Sports Injuries and Pain is a clinical manual that This large 10 1/2' x 8 1/4' paperback book.

Stomach Meridian

The stomach meridian is responsible for stomach problems including abdominal pain, distension, edema, vomiting; and also sore throat, facial paralysis, upper gum toothache, nose bleeding, and pain along the path of the meridian.

Spleen Meridian

The spleen meridian is the source of problems of the spleen and pancreas, abdominal distension, jaundice, general weakness, tongue problems, vomiting, pain and swellings along the path of the meridian.

Heart Meridian

The heart meridian is the source of heart problems, throat dryness, jaundice, and pain along the path of the meridian.

Small Intestine Meridian

Here we find the source of lower abdomen pain, sore throat, facial swelling or paralysis, deafness, and discomfort along the path of the meridian.

Bladder Meridian

This meridian serves as the location for diagnosing and treating bladder problems, headache, eye diseases, neck and back problems, and pain along the back of the leg.

Kidney Meridian

The kidney meridian is the source of kidney problems, lung problems, dry tongue, lumbago, edema, constipation, diarrhea, pain, and weakness along the meridian's path.

Pericardium Meridian

The pericardium meridian is the source of poor circulation, angina, palpitation, diseases of the sexual glands and organs, irritability, and pain along the pathway of the meridian.

About this mod. Adds 25 new high quality weapons from Prince of Persia Warrior Within to Skyrim. 2.Copy the contents of the archive in your Skyrim Data folder 3.Open the Skyrim launcher or your mod manager of choice and check the Prince of Persia-Warrior Within leather armor.esp Uninstall: ~~~~~ 1.Uncheck the esp plugin 2.Delete all files that came with the mod Known issue: ~~~~~.

Triple Burner Meridian

Here is the source of diseases of the thyroid and adrenal glands, ear problems, sore throat, abdominal distension, edema, swelling of cheek, and pain along the meridian's pathway.

Gallbladder Meridian

This meridian is the location for diagnosis and treatment of gallbladder problems, ear diseases, migraine, hip problems, dizziness, and pain along the meridian.

Liver Meridian

This meridian is the focal point for liver problems, lumbago, vomiting, hernia, urination problems, pain in the lower abdomen and along the pathway of the meridian.

Lung Meridian

The lung meridian is the source of respiratory diseases, sore throat, cough, common cold, pain in the shoulder, and pain and discomfort along the meridian pathway.

Large Intestine Meridian

Abdominal pain, constipation, diarrhea, sore throat, toothache in the lower gum, nasal discharge, and bleeding, pain along the course of the meridian

Associated Data

Abstract

Background

Ankle sprain is one of the most frequently encountered musculoskeletal injuries; however, the efficacy of acupuncture in treating ankle sprains remains uncertain. We therefore performed a systematic review to evaluate the evidence regarding acupuncture for ankle sprains.

Methods

We searched 15 data sources and two trial registries up to February 2012. Randomized controlled trials of acupuncture were included if they involved patients with ankle sprains and reported outcomes of symptom improvement, including pain. A Cochrane risk of bias assessment tool was used. Risk ratio (RR) or mean difference (MD) was calculated with 95% confidence intervals (CIs) in a random effects model. Subgroup analyses were performed based on acupuncture type, grade of sprain, and control type. Sensitivity analyses were also performed with respect to risk of bias, sample size, and outcomes reported.

Results

Seventeen trials involving 1820 participants were included. Trial quality was generally poor, with just three reporting adequate methods of randomization and only one a method of allocation concealment. Significantly more participants in acupuncture groups reported global symptom improvement compared with no acupuncture groups (RR of symptoms persisting with acupuncture = 0.56, 95% CI 0.42–0.77). However, this is probably an overestimate due to the heterogeneity (I² = 51%) and high risk of bias of the included studies. Acupuncture as an add-on treatment also improved global symptoms compared with other treatments only, without significant variability (RR 0.61, 95% CI 0.51–0.73, I² = 1%). The benefit of acupuncture remained significant when the analysis was limited to two studies with a low risk of bias. Acupuncture was more effective than various controls in relieving pain, facilitating return to normal activity, and promoting quality of life, but these analyses were based on only a small number of studies. Acupuncture did not appear to be associated with adverse events.

Conclusions

Given methodological shortcomings and the small number of high-quality primary studies, the available evidence is insufficient to recommend acupuncture as an evidence-based treatment option. This calls for further rigorous investigations.

Background

Acute ankle sprain is an acute injury of one or more of the ankle ligaments. Among the tendon and ligament injuries presenting to physicians, acute ankle sprain is one of the most commonly encountered musculoskeletal injuries in both athletes and sedentary people. Ankle sprains result in high costs to society due to increased healthcare resource use and work absence. It has been estimated that ankle sprain occurs at a rate of one injury per 10,000 people every day in the US, accounting for an estimated 2 million injuries per year and 20% of all sports injuries [,].

Ankle sprains are classified into three grades depending on the severity of the injury: grade I is mild stretching or partial tear of the anterior talofibular and/or calcaneofibular ligaments accompanied by mild tenderness and swelling but with slight or no functional loss; grade II is incomplete tear of ligaments with moderate pain, swelling, and functional loss; and grade III is characterized by complete tear of ligaments that results in severe swelling, pain, and loss of function and motion [].

The main goals of treatment are to relieve pain, maintain range of motion (ROM), return to pre-injury level, and prevent recurrence of injury. Among many different treatment options used for ankle sprains, the three major types of treatment are conservative, functional, and surgical. Conservative treatment means plaster cast immobilization and functional treatment indicates early mobilization using external supports (e.g. elastic bandage, tape, orthotic support) plus coordination training []. For patients with grade I or II injury, early use of PRICE (protection, rest, ice, compression, and elevation), ankle support, and maintaining ROM are necessary. For patients with grade III injury, surgical treatment is recommended []. In addition to these treatments, analgesics such as acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used as an adjunct. Therapeutic ultrasonography and short-wave diathermy are also commonly used, but there is little evidence to promote their use in terms of symptom relief [,].

In addition to conventional treatments for ankle sprains, complementary and alternative therapies such as herbs and homeopathy have been thought to relieve pain, reduce swelling, and help the body restore damaged tissue, but the evidence is limited [,]. Acupuncture, one of the most commonly used therapeutic modalities in complementary and alternative medicine, is used extensively for painful conditions [,]. One survey reported that 76% of responding American physicians used acupuncture for ankle sprain and 90% of them assessed its efficacy as very/somewhat effective []. In 2009, approximately 2.8 million Korean people were diagnosed with an ankle injury, making ankle injury the fifth most common reason for visits to Korean Medicine clinics, and of them 1.2 million sought acupuncture treatment [12]. Clinical experience and some animal studies indicate that ankle sprain responds rapidly to acupuncture, which alleviates the intensity and duration of pain, contributing to a prompt return to pre-injury activity [,14]. Given its popular use and claimed effectiveness, however, the evidence in support of acupuncture for treating ankle sprain remains unclear. Because there is no convincing information on the efficacy of acupuncture for ankle sprains, we decided to critically evaluate the evidence.

Methods

Eligibility criteria

Types of study

All randomized controlled trials (RCTs) evaluating acupuncture treatment for ankle sprains were considered.

Types of participant

Studies enrolling patients who reported an ankle sprain regardless of duration were eligible for inclusion. The diagnosis could be based on any method, including physical examination (positive anterior drawer test, pain, and swelling), arthrography, or a stress radiograph of the injured ankle. Trials including patients with congenital deformities, degenerative conditions, or fractures were excluded. Mixed population studies including adults and children were included.

Types of intervention

Top 10 Worst Sports Injuries

Acupuncture included needle acupuncture, ear acupuncture, electroacupuncture, pharmacopuncture (injection of herbal medicine into acupuncture points), bee venom acupuncture, scalp acupuncture, warm acupuncture, and moxibustion. Studies that assessed the combined effect of acupuncture plus other related treatments (e.g. acupuncture plus moxibustion) were also considered. We did not include trials testing non-penetrating acupuncture point stimulation (e.g. acupressure, transcutaneous electrical nerve stimulation (TENS), magnets). Trials comparing different forms of acupuncture were excluded because the efficacy of the control intervention could not be determined. Details of acupuncture interventions were extracted and tabulated based on the revised Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) [].

Types of control

For control groups, we considered placebo, usual care, and no intervention. Sham or placebo acupuncture intervention means use of a non-penetrating sham needle or superficial needling at non-acupuncture points. Usual care includes PRICE, analgesic drugs, functional exercise, and/or electrotherapy such as ultrasound or short waves. When acupuncture was given with other usual treatment, we included only those trials where identical usual treatment was administered to the acupuncture and control groups.

Types of outcome measure

The primary outcome of this systematic review was patient-reported global symptom improvement at the end of treatment. Pain intensity data were included in the review if data for global symptoms were not provided.

Secondary outcomes included time to achieve pre-injury level of work or sports, subjective (e.g. giving way) and objective (e.g. inversion stress test, talar tilt, anterior drawer test, postural sway analysis) evaluations of ankle instability, dichotomous (e.g. yes or no) and continuous (e.g. visual analog scale (VAS)) data regarding swelling, recurrence of ankle sprain, subsequent surgery, or long-term treatment, health-related quality of life (e.g. Short Form 36 (SF-36)), and adverse events related to acupuncture treatment.

Literature search

We searched the following databases from their inception to February 2012; Cochrane Central Register of Controlled Trials, PubMed, Ovid EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), SPORTDiscus, the Allied and Complementary Medicine Database (AMED), Rehabilitation and Sports Medicine Source, and the China National Knowledge Infrastructure databases (CNKI). We also searched Korean databases including the Oriental Medicine Advanced Searching Integrated System, the Korean Studies Information Service System, RISS4U, Korea Institute of Science and Technology Information, KOREAMED, DBPIA, and the Korea National Assembly Library. Ongoing trials were searched in trial registries at http://www.controlled-trials.com and http://www.clinicaltrials.gov. The reference lists of reviews and relevant articles were screened for additional studies.

Search terms used for the Cochrane Central Register of Controlled Trials were as follows: (“ankle injuries”[MeSH] OR “sprains and strains”[MeSH] OR “sprain*”[ti, ab, kw] OR “strain*”[ti, ab, kw] OR “injur*”[ti, ab, kw] OR “ankle*”[ti, ab, kw]) AND (“acupuncture”[MeSH] OR “acupuncture therapy”[MeSH] OR “acupunc*”[ti, ab, kw] OR “electroacupunc*”[ti, ab, kw] OR “meridian*”[ti, ab, kw] OR “acupoint*”[ti, ab, kw] OR “moxibustion*”[ti, ab, kw] OR “moxa*”[ti, ab, kw]). These search terms were slightly modified for other databases. Trials published in English, Korean, or Chinese were sought.

Study selection and data extraction

Two reviewers (Jimin Park and Ji-Yeun Park) independently reviewed all searched articles to evaluate their suitability for inclusion. If there was disagreement, it was resolved by discussion between the reviewers; further information was sought from the original authors if necessary.

After selection of studies, the aforementioned two reviewers independently extracted the following data from the selected articles: author, year of publication, country, study design, participants (age, gender), duration of disease, acupuncture intervention, control intervention, outcome measures, main results, and adverse events.

Risk of bias assessment

Two reviewers (Jimin Park and Ji-Yeun Park) independently evaluated risk of bias for the included studies according to the Cochrane Collaboration’s risk of bias assessment tool [16]. The evaluated items for risk of bias were as follows.

(1) Was the method of randomization sequence generation adequate?

(2) Was the treatment allocation adequately concealed?

(3) Was the patient blinded to the intervention?

(4) Was the outcome assessor blinded to the intervention?

(5) Were incomplete outcome data adequately addressed?

(6) Are reports of the study free of suggestion of selective outcome reporting?

The reviewers rated the risk of bias for each item using ‘Yes’, ‘Unclear’, or ‘No’; ‘Yes’ meant a low risk of bias, ‘Unclear’ meant uncertain or unknown risk of bias, and ‘No’ meant a high risk of bias. Disagreements were resolved by discussion between the reviewers.

Statistical analysis

Review Manager software (version 5.1 for Windows; The Nordic Cochrane Centre, Copenhagen, Denmark) was used for statistical analysis. Studies were classified and combined in the main analysis according to whether acupuncture was an alternative or an add-on treatment. Data were pooled using a random effects model. The impact of acupuncture on dichotomous data was expressed as the risk ratio (RR) of global symptoms persisting with the acupuncture intervention compared with the control, with 95% confidence intervals (CIs) (i.e. the RR of non-response). To define non-response, patient-reported global symptoms in ordinal assessments were divided into two groups (e.g. ‘poor’ or ‘good’ as non-response vs. ‘very good’ or ‘excellent’ as response). If different strata were used to define improvement, the cut-off point with the least improvement was taken (e.g. if the ordinal assessment was poor, good, or excellent, we utilized a poor vs. good or excellent comparison). In summary, a RR value of less than 1 indicated a lower risk of symptoms persisting or getting worse with acupuncture compared with the control. For continuous outcomes, the mean difference (MD) with a 95% CI was calculated.

Visual inspection of forest plots and a chi-square test with a significance level of p < 0.1 were used to assess heterogeneity among the included studies. To quantify inconsistencies among the studies, the I² test was used with a value of 50% or more considered to indicate a substantial level of heterogeneity []. Subgroup analyses were conducted in terms of acupuncture intervention (e.g. manual acupuncture, electroacupuncture), grade of ankle sprain, and control type (e.g. usual care, sham acupuncture). Sensitivity analyses were also planned by including only those studies with low risk of bias or studies with sample size ≥ 40 per arm, and by varying the grouping of outcome measures. We analyzed trials with a low risk of bias for randomization and/or allocation concealment only [,] and investigated whether the intervention effect was affected. Studies with ≥ 40 participants per arm were analyzed separately to see whether any difference in intervention effect emerged []. For outcome measures, because it is common for Chinese trials to report outcomes based on an ordinal assessment (e.g. ‘excellent’, ‘very good’, ‘good’, ‘poor’), we also performed a sensitivity analysis by reanalyzing the dichotomous outcomes; we compared the ‘excellent, very good vs. good, poor’ scenario from our original analysis with an ‘excellent, (very) good vs. poor’ scenario to ascertain any discrepancies.

Results

Description of studies

Our search terms yielded 387 records: five in the Cochrane Central Register of Controlled Trials, 21 in EMBASE, 42 in the CINAHL, 10 in SPORTDiscus, 10 in the AMED, two in Rehabilitation and Sports Medicine Source, 175 in the CNKI, 90 in PubMed, and 32 in the relevant Korean journals. After duplicate studies had been removed, 380 records were screened. Based on the title and abstract, 322 records were excluded; 162 articles were not specific to the topic of the review and 160 were not clinical studies or were non-randomized trials. Of the remaining 58, further studies were excluded as follows. (1) Thirty-seven studies did not satisfy the inclusion criteria for acupuncture or the control intervention: these were studies that compared different acupuncture styles (n = 9); studies of acupuncture vs. Chinese herbal medicine or bee venom, the efficacy of which has not been established (n = 8); trials where acupuncture was given with other therapies so that the effect of acupuncture per se could not be isolated (n = 9); and trials comparing the effect of another therapy given with acupuncture with that of acupuncture alone (n = 11). (2) One study published in French was excluded, and (3) we failed to obtain the full texts of three studies. Finally, 17 studies were included in our review and 16 studies reporting patient-reported global assessment outcome were pooled in the main analysis. Figure 1 shows a flow diagram of the literature search as recommended in Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) [].

Flow diagram of literature search.

Characteristics of the included studies

Details of the included studies are summarized in Tables 1 and ​and22 and Additional file 1.

Table 1

*, cured/significantly improved/improved/failed; †, for outcome measure 1); ‡, for outcome measure 2); §, cured/improved/failed.

**, decrease rate ≥ 5/decrease rate ≤ 5 (mean score of pain and swelling).

††, significantly improved/improved/failed.

‡‡, cured/significantly improved/improved.

There were 4 trials which reported acupuncture alone vs. other treatment and acupuncture plus other treatment vs. other treatment [33-35,40]. They were put as acupuncture as an add-on treatment trials in this table.

d indicates days; EA, electroacupuncture; h, hours; HM, herbal medicine; IR, infrared radiation; MA, manual acupuncture; no., number; NS, no significant difference between groups; NSAIDs, non-steroidal anti-inflammatory drugs; PRGA, patient-reported global assessment; PRICE, protection, rest, ice, compression and elevation; QOL, quality of life; TENS, transcutaneous electrical nerve stimulation; VAS, visual analog scale; WA, warm acupuncture; wks, weeks; yrs, years.

Table 2

Summarized acupuncture interventions in the included studies

*, Acupuncture method was classified into three categories based on the levels of individualization: ‘fixed’ means all patients receive the same treatment at all sessions, ‘partially individualized’ means using a fixed set of points to be combined with a set of points to be used flexibly, and ‘individualized’ means each patient receives a unique and evolving diagnosis and treatment []; **, Acupuncture point LI5 refers to 5th point of large intestine meridian and extra points have different nomenclature (e.g., Ex-UE3 means 3rd extra point in upper extremity). Ashi points mean local pain points; ***, De-qi means acupuncture-evoked specific sensations such as soreness, numbness, heaviness, and distention at the site of needle placement and these sensations may spread to other parts of the body.

d indicates days; EA, electroacupuncture; HM, herbal medicine; IR, infrared radiation; MA, manual acupuncture; n.r., not reported; NSAIDs, non-steroidal anti-inflammatory drugs; PRICE, protection, rest, ice, compression and elevation; TCM, traditional Chinese medicine; WA, warm acupuncture; wks, weeks.

Participants

Seventeen studies involving 1820 participants were included in our review. All were conducted in China and were published in Chinese. When divided into acute, chronic, and mixed ankle sprains based on a cut-off point of 6 months after onset [,], 12 studies [24-35] involved participants with acute ankle sprain, three studies [36-38] involved mixed participants, no study involved participants with chronic ankle sprain only, and one study [39] did not report disease duration but it was assumed that the participants had acute ankle sprain. Another study [40] mentioned ‘acute’ in the title, but 326 participants had had sprained ankles for less than 2 days and the other 12 for more than 3 days. Regarding the severity of the sprain, only four trials clearly reported that the participants had grade I or II injuries [24,28,31,39].

Acupuncture intervention

Highly variable acupuncture interventions were given either alone or as an add-on to the control intervention. Of the 17 included studies, nine [24-26,31-35,40] tested manual acupuncture, four [27,30,38,39] used electroacupuncture, three [28,36,37] used warm acupuncture, and one [] used warm acupuncture in addition to manual acupuncture. Of five trials that assessed the effect of acupuncture alone, three studies evaluated electroacupuncture [27,30,39]; one each evaluated warm acupuncture [28] and manual acupuncture [26]. Fixed (i.e. all participants received the same treatment), partially individualized (using a fixed set of points with a further set of points to be used flexibly), and individualized (each participant received tailored treatment) acupuncture treatments were given; of the 17 studies, seven used fixed [24,25,30,33-35], six used partially individualized [26,27,31,38-40], and four used individualized treatments [28,32,36,37]. The number of acupuncture sessions ranged from three to 15 over 3 days to 4 weeks. De-qi – acupuncture-evoked specific sensations such as numbness, heaviness, soreness, or distention – was sought in 11 studies [24-27,-31,36-39]. Fourteen studies [24-27,-31,33-35,37-40] used 12 meridian points and/or extra points; two studies [28,36] used tender points, and one study [32] did not report the acupuncture points used. Details of acupuncture interventions are summarized in Table 2 based on the revised STRICTA [].

Control intervention

The Acupuncture Handbook Of Sports Injuries & Pain

A range of control interventions were used, including ice pack, exercise, bandage, analgesic drugs, herbal medicine, infrared radiation, tuina massage, hot pack, and TENS. No study adopted sham acupuncture as a control treatment (Table 1). More than one comparison group was used in five trials [33-36,40]. In nine trials evaluating the effect of acupuncture alone, usual care [26,27,30,33-35] or infrared radiation [26,28,39] was used as a control. Two studies adopted hot pack [26,30] or herbal medicine [26,35] as a control treatment. Only one study [40] used tuina massage. Of the other 12 trials testing acupuncture as an add-on treatment, seven [24,25,33-36] employed usual care and three used herbal medicine [31,32,35] or tuina massage [37,38,40]. One each adopted infrared radiation [38] and TENS [37].

Outcome measures

Outcome measures reported in the included studies were patient-reported global assessment (16 trials) [24-27,-35,37-40], pain (one trial) [36], time to return to pre-injury level of work or sports (four trials) [24-26,], recurrence rate (one trial) [38], health-related quality of life (one trial) [36], and adverse events (two trials) [34,35]. For patient-reported global assessment outcomes, a range of definitions was used to assess efficacy. We thus used the proportion of participants who had poor or good improvement (i.e. non-responders) in the main analysis.

Risk of bias in the included studies

Most of the included trials were assessed as having a high risk of bias. Just three of the 17 studies reported an adequate method of sequence generation such as using a random number table or coin tossing [24,31,36]; among these, group assignment was adequately concealed using sealed opaque envelopes in only one trial [24]. For participant and personnel blinding, no trial was rated as having a low risk of bias because none of the trials was sham-controlled. Outcome measures were assessed by non-blinded participants in three studies [24,27,33]; the other 14 studies were rated as having an unclear risk of bias because we could not completely exclude the possibility that a blinded third party assessor might have evaluated global symptom improvement. All but one trial were assessed as having a low risk of bias because of having no missing outcome data; one study [24] did not report the number of participants analyzed in the outcome measure. Regarding selective outcome reporting, we could not locate and compare the protocols of any of the included studies; hence, we judged the risk of bias based on the described methods in each study. Six studies had a high risk of bias for selective outcome reporting because they were reporting unplanned outcome measurements [24-26,37,38] (Table 3).

Table 3

*, Based on the risk of bias assessment tool from the Cochrane Handbook for Systematic Reviews of Interventions [16]; ‘Y’ indicates “Yes (low risk of bias)”; ‘U’, “Unclear”; ‘N’, “No (high risk of bias)”; A study with a low risk of bias was defined as a study receiving ‘Y’ for randomization and/or allocation concealment.

Effects of acupuncture on primary outcome

The key outcomes from the included studies are provided in Table 1 and Figure 2. We evaluated primary outcomes of patient-reported global assessment. Pain was considered if a global assessment was not available.

Effects of acupuncture for ankle sprains according to the acupuncture as an alternative or add-on treatment.

Effects of acupuncture as an alternative treatment

Nine trials with 797 participants [26-28,30,33-35,39,40] reported global symptom improvement as a dichotomous outcome. Approximately nine sessions of acupuncture were given over 11.5 days. Acupuncture had a statistically significant effect in reducing the global symptoms of ankle sprain (RR of symptoms persisting with acupuncture = 0.56; 95% CI 0.42–0.77; Figure 2 (A)). However, there was substantial heterogeneity among the trials (χ² = 16.38, degrees of freedom (df) = 8, p = 0.04, I² = 51%).

Effects of acupuncture as an add-on treatment

Eleven trials with 926 participants reported the add-on effect of acupuncture [24,25,31-35,37,38,40]. A median of 10 sessions of acupuncture over nine days was provided. When added to other treatment, acupuncture statistically significantly improved global symptoms compared with the other treatment only (RR of symptoms persisting with acupuncture = 0.61; 95% CI 0.51–0.73; Figure 2 (B)). There was no significant heterogeneity among the studies (χ² = 10.08, df = 10, p = 0.43, I² = 1%).

Effects of acupuncture on pain intensity

One study reported pain intensity on a VAS both immediately and more than 2 years after treatment [36]. Immediately after treatment, warm needling significantly alleviated pain compared with the control group (1.32 ± 0.42 vs. 6.55 ± 1.76, MD –5.23, 95% CI –5.61 to –4.85). At long-term follow-up of 28.8 months on average, the analgesic effect was maintained (1.01 ± 0.15 vs. 5.89 ± 1.93, MD –4.88, 95% CI –5.29 to –4.47).

Effects of acupuncture on secondary outcomes

Sports Injuries Elbow

Time to achieve pre-injury level of work or sports

Four studies reported time to cure [24-26,]. Of these, one study [24] reported that acupuncture in addition to functional exercise shortened the time to return to normal activity by 3.4 days compared with a functional exercise only group (5.2 ± 0.7 vs. 8.6 ± 1.4, MD –3.40, 95% CI –3.88 to –2.92). In the other three studies [25,26,], participants were no more likely to have recovered within 1 week than were those in the control group, regardless of whether they were given acupuncture as an add-on (two trials, RR 2.49, 95% CI 0.60 to 10.29, I² = 0%) or an alternative treatment (one trial, RR 1.21, 95% CI 0.99–1.47).

Ankle instability and swelling

No included study reported on ankle instability and/or swelling as a separate outcome measure; most of the studies reported a composite measure of patient-reported global symptoms.

Recurrence of ankle sprain

One study [38] reported that one participant in the acupuncture group and five in the control group had suffered a re-injury at 6-month follow-up (RR 0.17, 95% CI 0.02–1.33).

Health-related quality of life

One study [36] reported quality of life using the SF-36 immediately and more than 2 years after treatment. Immediately after treatment, the acupuncture group reported significantly better quality of life than the control group (91.25 ± 10.16 vs. 76.53 ± 5.24, MD 14.72, 95% CI 12.32–17.12). At 2-year follow up, the effect remained significant (93.62 ± 9.05 vs. 62.31 ± 6.67, MD 31.31, 95% CI 28.95–33.67).

The Acupuncture Handbook Of Sports Injuries Pain Pdf Writer Free

Adverse events

Two studies [34,35] reported mild adverse events such as a mild allergic response to medication, from which the patients (three participants) recovered after the drug was stopped.

Subgroup analyses

We conducted subgroup analyses based on the following predefined characteristics: type of acupuncture intervention, grade of ankle sprain, and control type.

Acupuncture type

Manual acupuncture [24,25,31-35,40] had an additional effect on symptom improvement compared with controls (eight trials, RR 0.62, 95% CI 0.50–0.77, I² = 0%). When manual acupuncture was given as an alternative [26], the RR of symptoms persisting with acupuncture was 0.20 (95% CI 0.06–0.65). Electroacupuncture as a sole treatment [27,30,39] had no significant benefit compared with oral/topical NSAIDs or infrared radiation (three trials, RR 0.50, 95% CI 0.20–1.22, I² = 76%). When added to massage and infrared radiation [38], the effect of electroacupuncture was statistically significantly better than that of massage and infrared radiation only (one trial, RR 0.11, 95% CI 0.01–0.82).

Grade of ankle sprain

There were insufficient data for subgroup analysis of sprain severity. Only four trials [24,28,31,39] clearly reported that their participants had grade I or II injuries; the RR of symptoms persisting with acupuncture was 0.39 (two trials, 95% CI 0.18–0.88, I² = 0%) when acupuncture was given as an add-on treatment and 0.35 (two trials, 95% CI 0.17–0.71, I² = 0%) when it was an alternative treatment.

Control type

1. Acupuncture vs. oral/topical NSAIDs

(1) Acupuncture vs. NSAIDs

Two trials with 122 participants tested the effect of acupuncture on global symptom improvement against oral/topical NSAIDs [27,30]. There was no statistically significant difference between the groups (Figure 3 (A1); RR 0.64, 95% CI 0.29–1.39, I² = 67%).

Effects of acupuncture for ankle sprains according to the control groups.

(2) Acupuncture plus NSAIDs vs. NSAIDs

Acupuncture had no additional effect on global symptom improvement compared with oral/topical NSAIDs only [33,34] (Figure 3 (A2); RR 0.72, 95% CI 0.50–1.05, I² = 22%).

2. Acupuncture plus herbal medicine vs. herbal medicine

Symptoms persisted in significantly fewer participants when acupuncture was added to oral/topical herbal medicine compared with the medicine alone [31,32,35] (Figure 3 (B); RR 0.56, 95% CI 0.40–0.78, I² = 0%).

Sensitivity analyses

We performed sensitivity analyses by excluding studies with predefined less desirable characteristics, as follows.

Risk of bias

When the analysis was limited to two studies with a low risk of bias for random sequence generation and/or allocation concealment [24,31], the add-on effect of acupuncture on patient-reported global assessment remained significant (RR 0.39, 95% CI 0.18–0.88, I² = 0%).

Sample size

When four studies with ≥ 40 participants per group [24,26,33,40] were pooled, there was no significant difference in the risk of symptoms persisting or worsening between the acupuncture and control groups (RR 0.50, 95% CI 0.24–1.05, I² = 55%).

Outcome measures

For 16 studies reporting a dichotomous outcome based on an ordinal assessment, we compared the ‘excellent, very good’ vs. ‘good, poor’ scenario (16 trials, RR 0.55, 95% CI 0.45–0.69, I² = 40%) with an ‘excellent, (very) good vs. poor’ scenario (RR 0.26, 95% CI 0.18–0.38, I² =0%); the difference remained significant without variability.

Discussion

Summary of evidence

Youth Sports Injuries

This systematic review aimed to assess the evidence in support of acupuncture treatment for ankle sprains. Seventeen RCTs were included that investigated the effect on global symptom improvement of acupuncture as an alternative or an add-on to other treatment. In the evaluation of acupuncture compared with other treatments, acupuncture had a therapeutic benefit in improving global symptoms (RR of symptoms persisting with acupuncture = 0.56, 95% CI 0.42–0.77). However, this is probably an overestimate due to the heterogeneity (I² = 51%) and high risk of bias of the included studies.

Compared with other treatments alone, acupuncture as an adjunct significantly alleviated the global symptoms of ankle sprain without significant variability (RR of symptoms persisting with acupuncture = 0.61, 95% CI 0.51–0.73).

A sensitivity analysis of the trials with a low risk for selection bias suggested that the beneficial effect of acupuncture was maintained. The effect of acupuncture was no more significant when the analysis was limited to studies with adequate sample size. Acupuncture was more effective than various controls in relieving pain, facilitating return to normal activity, and promoting quality of life, but these analyses were based on only a small number of studies. Acupuncture did not appear to be associated with serious adverse events, but the evidence is limited.

Risk of bias

Most of the included studies suffered from a serious risk of bias. Only three studies had a low risk of bias for adequate randomization and/or allocation concealment. It is well known that inadequate allocation concealment/random sequence generation leads to overestimation of treatment effects [,]. Although the included studies uniformly reported no difference in baseline characteristics between groups, we cannot exclude the possibility that selection bias may have played a role. However, when we limited our main analysis to those studies rated as having a low risk of bias for randomization/allocation concealment, the benefit of acupuncture remained significant.

Because of the small number of studies, we could not formally test for funnel plot asymmetry to detect small-study effects (a tendency for the intervention effects detected in smaller studies to differ from those in larger studies []). Chinese studies may have been more likely to publish positive outcomes [,], but more importantly, the effect size of small studies in this review may have been inflated because of poor methodological design and conduct []. Because it is well known that small, poor-quality studies tend to spuriously inflate the effect of an intervention, we need to be more conservative in the interpretation of such results.

Limitations of this review

Although we made every endeavor to find all relevant trials in a range of databases and related journals, comprehensive searches do not necessarily remove publication bias or language bias. All trials were conducted in China and published in Chinese journals in the Chinese language. Egger et al.[] reported that inclusion of studies published in non-English languages or in journals that are not indexed in Medline is likely to increase the degree of funnel plot asymmetry in systematic reviews, and this may be relevant to the present review.

The included trials were mostly of poor quality; thus, the reported data are likely to be overestimated. In addition, the small sample size of the studies may have resulted in heterogeneity of the effect size. Moore et al.[] reported in a simulation study that at least 40 participants per arm are required to obtain clinically relevant results in trials relating to pain. Our sensitivity analysis based on sample size (i.e. trials with ≥ 40 per group only [24,26,33,36]) found no significant benefit from acupuncture.

Finally, as is usual in Chinese acupuncture trials, most of the studies in our review used various subjective outcomes. Because no study compared acupuncture with sham acupuncture, this makes outcome assessment blinding even more crucial. Failure to blind outcome assessment may have influenced the studies’ results.

Implications for practice

This systematic review suggests that there is insufficient high-quality evidence supporting the use of acupuncture as an alternative treatment to improve global symptoms of ankle sprain. Acupuncture provided a significant benefit as an add-on treatment and a sensitivity analysis of high-quality trials supports this finding, but the number of studies is too small to strongly recommend this use.

There are several issues worth considering before we make any judgments on the use of acupuncture for ankle sprain in practice. First, the tested acupuncture interventions varied widely across the trials in terms of type, points, number of sessions, and duration of treatment. Thus, it is difficult to determine whether these interventions were truly adequate or optimal.

Second, the control interventions used in the included studies also varied; they included usual care (e.g. ice pack, exercise, bandage, analgesics), herbal medicine, infrared radiation, tuina massage, hot pack, and TENS. Studies on the efficacy of topical NSAIDs compared with oral NSAIDs in the treatment of acute pain were conducted recently due to the adverse effects of oral NSAIDs such as gastrointestinal complications and cardiovascular toxicity. In a review of their use for musculoskeletal pain [], topical NSAIDs were found to have comparable efficacy and better safety compared with oral NSAIDs when used for acute pain including sprains and strains, and the effect of topical NSAIDs was 1.6 times better than that of placebo at 7 days. In the present review, acupuncture as an add-on or alternative treatment had no better effect than oral/topical NSAIDs but was associated with few side effects. Acupuncture was significantly effective for symptom improvement only when added to oral/topical herbal medicine.

Third, the outcome measures of the included studies were not consistent. The clinical relevance of any benefit of acupuncture is not obvious [46], and because there are no reliable data on the minimal clinically important difference relating to patient-reported global symptom improvement in ankle sprain, we may only infer that the effect of acupuncture is small [46].

The Acupuncture Handbook Of Sports Injuries Pain Pdf Writer

Fourth, all of the trials included in this review were conducted in China. Acupuncture may be highly culture specific and further research is necessary to investigate whether the interventions reported here are applicable to and acceptable in other countries. Undergoing acupuncture every day may not be a feasible treatment schedule outside China.

Sports Injuries Statistics

Lastly, clinically meaningful information on the severity of injury and follow-up data were sparse in the included trials. Thus, the available evidence prevents us from determining whether the effects of acupuncture varied with the severity of injury or how long its benefit was maintained.

In summary, evidence supporting the use of acupuncture in patients with ankle sprain is currently inconclusive.

Implications for research

To obtain a more definitive answer to the question of the efficacy of acupuncture for ankle sprain, we need more carefully designed and conducted trials. Researchers should use adequate randomization methods and ensure that group assignment is adequately concealed, because these are both critical in avoiding systematic differences between the baseline characteristics of the groups that are compared (i.e. selection bias). Because it is almost impossible for the therapist to be blinded to the acupuncture intervention provided, it may be more important to blind the participants and outcome assessor. There was no study with sham control in this review, so performance bias is likely to have played a part in our findings.

In the future, a sham-controlled trial is needed to avoid performance bias. To maintain outcome assessor blinding, validated assessment tools are required. Recent studies have tested the validity, reliability, and responsiveness of relevant scales [,]. For example, a study has tested the validity and responsiveness of the ankle functional score (AFS) based on fundamental functional outcomes such as pain, swelling, weight bearing, stability, and gait, and concluded that the AFS is easy to use and might be employed alongside subjective clinical assessment to evaluate recovery after acute ankle sprain []. Using not only subjective patient-reported symptom improvement, but also validated outcome measures, and ensuring outcome assessment blinding, should be considered for future trials.

Conclusions

Given the methodological flaws of the included studies, the available evidence is insufficient to recommend acupuncture as an evidence-based treatment option for ankle sprain. Further well-designed and conducted trials are needed to draw a definitive conclusion.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

HSL and JMP designed this review, searched databases, and screened trials for inclusion. JMP and JYP extracted data, evaluated studies and it was checked by HSL. HSL and JMP performed analyses and discussed with HJP and SKH. All authors read and approved the final manuscript.

Pre-publication history

The pre-publication history for this paper can be accessed here:

Supplementary Material

Characteristics of the included studies.

Acknowledgements

This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Korean Ministry of Education, Science and Technology (Nos. 2005-0049404 and 2012R1A1A2006793). We thank Ms. Xiuyu Zhang at Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Korea, for helping us get additional information from original authors of the included trials.

References

• Beynnon BD, Renstrom PA, Haugh L, Uh BS, Barker H. A prospective, randomized clinical investigation of the treatment of first-time ankle sprains. Am J Sports Med. 2006;34(9):1401–1412. doi: 10.1177/0363546506288676. [PubMed] [CrossRef] [Google Scholar]
• Beynnon BD, Renstrom PA, Alosa DM, Baumhauer JF, Vacek PM. Ankle ligament injury risk factors: a prospective study of college athletes. J Orthop Res. 2001;19(2):213–220. doi: 10.1016/S0736-0266(00)90004-4. [PubMed] [CrossRef] [Google Scholar]
• Wolfe MW, Uhl TL, Mattacola CG, McCluskey LC. Management of ankle sprains. Am Fam Physician. 2001;63(1):93–104. [PubMed] [Google Scholar]
• Kerkhoffs GM, Struijs PA, Marti RK, Assendelft WJ, Blankevoort L, Van vDijk CN. Different functional treatment strategies for acute lateral ankle ligament injuries in adults. Cochrane Database Syst Rev. 2002;3:CD002938. [PubMed] [Google Scholar]
• Ogilvie-Harris DJ, Gilbart M. Treatment modalities for soft tissue injuries of the ankle: a critical review. Clin J Sport Med. 1995;5(3):175–186. doi: 10.1097/00042752-199507000-00008. [PubMed] [CrossRef] [Google Scholar]
• van den Bekerom MP, van der Windt DA, Ter Riet G, van der Heijden GJ, Bouter LM. Therapeutic ultrasound for acute ankle sprains. Cochrane Database Syst Rev. 2011;6:CD001250. [PubMed] [Google Scholar]
• Koll R, Buhr M, Dieter R, Pabst H, Predel HG, Petrowicz O, Giannetti B, Klingenburg S, Staiger C. Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. Phytomedicine. 2004;11(6):470–477. doi: 10.1016/j.phymed.2004.02.001. [PubMed] [CrossRef] [Google Scholar]
• Schneider C, Schneider B, Hanisch J, Van Haselen R. The role of a homeopathic preparation compared with conventional therapy in the treatment of injuries: an observational cohort study. Complement Ther Med. 2008;16(1):22–27. doi: 10.1016/j.ctim.2007.04.004. [PubMed] [CrossRef] [Google Scholar]
• Edwards E, Louis Belard J, Glowa J, Khalsa P, Weber W, Huntley K. DoD-NCCAM/NIH Workshop on Acupuncture for Treatment of Acute Pain. J Altern Complement Med. 2012. [PMC free article] [PubMed] [CrossRef]
• Vickers AJ, Cronin AM, Maschino AC, Lewith G, MacPherson H, Foster NE, Sherman KJ, Witt CM, Linde K. Acupuncture for chronic pain: individual patient data meta-analysis. Arch Intern Med. 2012;172(19):1444–1453.[PMC free article] [PubMed] [Google Scholar]
• Diehl DL, Kaplan G, Coulter I, Glik D, Hurwitz EL. Use of acupuncture by American physicians. J Altern Complement Med. 1997;3(2):119–126. doi: 10.1089/acm.1997.3.119. [PubMed] [CrossRef] [Google Scholar]
• Corporation NHI. National Health Insurance Statistical Yearbook. Seoul: National Health Insurance Corporation, Health Insurance Review & Assessment Service; 2010. [Google Scholar]
• Koo ST, Lim KS, Chung K, Ju H, Chung JM. Electroacupuncture-induced analgesia in a rat model of ankle sprain pain is mediated by spinal alpha-adrenoceptors. Pain. 2008;135(1–2):11–19.[PMC free article] [PubMed] [Google Scholar]
• An SS, Jang HK, Heo DS. The clinical effects of heating-conduction acupuncture therapy (tentatively called) for anterior talofibular ligament injury induced by acute ankle sprain. J Oriental Rehab Med. 2009;19(4):127–134.[Google Scholar]
• MacPherson H, Altman DG, Hammerschlag R, Youping L, Taixiang W, White A, Moher D. Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): extending the CONSORT statement. PLoS Med. 2010;7(6):e1000261. doi: 10.1371/journal.pmed.1000261.[PMC free article] [PubMed] [CrossRef] [Google Scholar]
• Higgins J, Altman D. In: Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 (updated March 2011) edn. Higgins J, Green S, editor. Chichester: The Cochrane Collaboration and John Wiley & Sons Ltd; 2011. Assessing risk of bias in included studies; pp. 187–241. [Google Scholar]
• Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–1558. doi: 10.1002/sim.1186. [PubMed] [CrossRef] [Google Scholar]
• Carroll D, Tramèr M, McQuay H, Nye B, Moore A. Randomization is important in studies with pain outcomes: systematic review of transcutaneous electrical nerve stimulation in acute postoperative pain. Br J Anaesth. 1996;77(6):798–803. doi: 10.1093/bja/77.6.798. [PubMed] [CrossRef] [Google Scholar]
• Pildal J, Hróbjartsson A, Jørgensen KJ, Hilden J, Altman DG, Gøtzsche PC. Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials. Int J Epidemiol. 2007;36(4):847–857. doi: 10.1093/ije/dym087. [PubMed] [CrossRef] [Google Scholar]
• Moore RA, Gavaghan D, Tramèr MR, Collins SL, McQuay HJ. Size is everything–large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects. Pain. 1998;78(3):209–216. doi: 10.1016/S0304-3959(98)00140-7. [PubMed] [CrossRef] [Google Scholar]
• Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–269. W264. [PubMed] [Google Scholar]
• Karlsson J, Eriksson BI, Bergsten T, Rudholm O, Sward L. Comparison of two anatomic reconstructions for chronic lateral instability of the ankle joint. Am J Sports Med. 1997;25(1):48–53. doi: 10.1177/036354659702500109. [PubMed] [CrossRef] [Google Scholar]
• Karlsson J, Bergsten T, Lansinger O, Peterson L. Surgical treatment of chronic lateral instability of the ankle joint. A new procedure. Am J Sports Med. 1989;17(2):268–273. doi: 10.1177/036354658901700220. discussion 273-264. [PubMed] [CrossRef] [Google Scholar]
• Sun C, Ju YY. Evaluation on the effect of acupuncture in the acute ankle sprain induced by football [in Chinese] Mod Prev Med. 2011;38(10):1890–1891.[Google Scholar]
• Zheng Q, Wang L. Therapeutic effects of puncturing Jianyu (LI 15) on sprain of external ankle joint [in Chinese] J. 2010;16(5):600–601.[Google Scholar]
• Ni XP, Li YJ. Observation of clinical efficacy of needling xiaojie point for sprain of ankle joints [in Chinese] Nei Mongol J Trad Chin Med. 2010;18:38.[Google Scholar]
• Luo W, He SW, Chen YQ. Clinical observation of electroacupuncture in treating chronic ankle injury [in Chinese] Shanghai J Trad Chin Med. 2009;43(10):43–44.[Google Scholar]
• Zhou RT. Twenty six cases of acute ankle sprain treated by warm needling on tenderness points [in Chinese] Clin J Trad Chin Med. 2008;20(2):174.[Google Scholar]
• He XF, Xu HB. Observation on therapeutic effect of acupuncture at Yanglingquan (GB 34) on sprain of external ankle joint [in Chinese] Zhongguo Zhen Jiu. 2006;26(8):569–570. [PubMed] [Google Scholar]
• Zhao YZ. Therapeutic effects of electroacupuncture plus point-penetration for chronic ankle joint sprain [in Chinese] Shanghai J Acupuncture Moxibustion. 2005;24(7):31.[Google Scholar]
• Li X. Clinical observation of acupuncture treatment of ankle sprains [in Chinese] J Chin Physic. 2002;30(7):46.[Google Scholar]
• Ge S, Ma Y. Eighty cases of ankle sprain treated by acupuncture combined with HuoXueLiShui Method [in Chinese] J Nanjing Univ Trad Chin Med. 2000;16(4):237.[Google Scholar]
• Yu J. Observation of curative effects of dolobene plus acupuncture on ankle joint sprain [in Chinese] Nat Sci J Hainan Univ. 1999;17(4):374–375.[Google Scholar]
• Yu J. Comprehensive treatment of dolobene, cold compress and acupuncture on ankle sprain: a report of 30 cases [in Chinese] Chin J Sports Med. 1999;18(3):279–280.[Google Scholar]
• Yu J, Shuo Y. Clinical observation of comprehensive treatment of new vulnerary, cold compress and acupuncture on ankle sprain [in Chinese] Nat Sci J Hainan Univ. 1996;14(1):62–63.[Google Scholar]
• He LY, Diao SL, He Y, Zhang CT, Deng DX, Shao JL, Li ZR. Effect on improvement of silver needle acupuncture moxibustion therapy on ankle injury [in Chinese] Liaoning J Trad Chin Med. 2010;37(10):2006–2008.[Google Scholar]
• Wei GK. 30 cases of chronic ankle sprain treated by massage combined with warm acupuncture [in Chinese] Zhejiang J Trad Chin Med. 2010;45(5):366.[Google Scholar]
• Tang WJ, Jiang CG, Zhong WF, Zhu BY, Pang Y. Clinical observation of 30 cases of exercise-induced lateral ankle ligament injury late pain treated by acupuncture, massage and TDP [in Chinese] Jiangsu J Trad Chin Med. 2010;42(8):55–56.[Google Scholar]
• Wang XL. Clinical observation of therapeutic effect of electroacupuncture on lateral ankle ligament sprain [in Chinese] Mod J Int Trad Chin Western Med. 2005;14(2):168.[Google Scholar]
• Ruan ZQ. Comparative observation of therapeutic effect of acupuncture plus massage on acute ankle sprains: 338 cases [in Chinese] J Ningde Teacher’s College. 1995;7(2):63–64.[Google Scholar]
• Sterne JA, Gavaghan D, Egger M. Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol. 2000;53(11):1119–1129. doi: 10.1016/S0895-4356(00)00242-0. [PubMed] [CrossRef] [Google Scholar]
• Vickers A, Goyal N, Harland R, Rees R. Do certain countries produce only positive results? A systematic review of controlled trials. Control Clin Trials. 1998;19(2):159–166. doi: 10.1016/S0197-2456(97)00150-5. [PubMed] [CrossRef] [Google Scholar]
• Egger M, Jüni P, Bartlett C, Holenstein F, Sterne J. How important are comprehensive literature searches and the assessment of trial quality in systematic reviews? Empirical study. Health Technol Assess. 2003;7(1):1–76. [PubMed] [Google Scholar]
• Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–634. doi: 10.1136/bmj.315.7109.629.[PMC free article] [PubMed] [CrossRef] [Google Scholar]
• Haroutiunian S, Drennan DA, Lipman AG. Topical NSAID therapy for musculoskeletal pain. Pain Med. 2010;11(4):535–549. doi: 10.1111/j.1526-4637.2010.00809.x. [PubMed] [CrossRef] [Google Scholar]
• Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2. New Jersey: Lawrence Erlbaum Associates; 1988. [Google Scholar]
• Coster M, Karlsson MK, Nilsson JA, Carlsson A. Validity, reliability, and responsiveness of a self-reported foot and ankle score (SEFAS) Acta Orthop. 2012;83(2):197–203. doi: 10.3109/17453674.2012.657579.[PMC free article] [PubMed] [CrossRef] [Google Scholar]
• van der Wees P, Hendriks E, Van Beers H, Van Rijn R, Dekker J, De Bie R. Validity and responsiveness of the ankle function score after acute ankle injury. Scand J Med Sci Sports. 2012;22(2):170–174. doi: 10.1111/j.1600-0838.2010.01243.x. [PubMed] [CrossRef] [Google Scholar]